The four creator gods of Heroshi are the most powerful deities. Ameadaeus rose to the ranks of greater deity due to his unrelenting desire for power, yet he is not yet as powerful as the four. Lesser beings can ascend to godhood by reward of an existing deity or deities, killing a demigod, or by "rite of ascention" (which involves gathering worshipers and creating a relic, among other tasks). Mortals cannot harm gods, but can harm and kill demigods. It's just really difficult. Gods are active in the world, but generally don't interfere in mortal affairs unless it suits their business. Usually they send agents to aid those who call upon them; outsiders such as inevitables, angels, devils, demons, archons, and guardinals are common choices. While deities powers are enhanced by having faithful worshippers, it is not required to remain deific. 

Divine Connections

Galen vs Drand - Unity vs. Bigotry

Cura vs Hemopha - Life vs. Death

Cura vs Dyldos - Purity vs. Hedonism

Gohdas vs Ameadaeus - Mankind vs. Monsterkind (Daema)

Cylphied vs. Edenova - Order vs. Destruction

Lor vs Malhavoc & Sorric - Truth vs Lies

Triad of Absolute Order - Drand, Ebonthorne, & Sorric

Triumvirate of Virtue - Lor, Cura, & Galen

Triumvirate of Taint - Ebonthorne, Nimis, & Dragmar

Deities by Alignment

There seems to be a bent toward chaos in Heroshi. 

Deities by Class and Alignment